Abstract Background Meta-analysis is increasingly used as Functional Glassware a key source of evidence synthesis to inform clinical practice.The theory and statistical foundations of meta-analysis continually evolve, providing solutions to many new and challenging problems.In practice, most meta-analyses are performed in general statistical packag
Application of Modelling and Simulation Approaches to Predict Pharmacokinetics of Therapeutic Monoclonal Antibodies in Pediatric Population
Ethical regulations and limited paediatric participants are key challenges that contribute to a median delay of 6 years in paediatric mAb approval.To overcome these barriers, modelling and simulation methodologies have been adopted to design optimized paediatric clinical studies and reduce patient burden.The classical modelling approach in paediatr
Identification of Vitamin D-related gene signature to predict colorectal cancer prognosis
Colorectal cancer (CRC) is one of the most common malignant carcinomas worldwide with poor prognosis, imposing an increasingly heavy burden on patients.Previous experiments and epidemiological studies have shown that vitamin D and vitamin D-related genes play a vital role in CRC.Therefore, we aimed to construct a vitamin D-related gene signature to
Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism.
The protein kinase Mec1 (ATR ortholog) and its partner Ddc2 (ATRIP ortholog) play a key role in DNA damage checkpoint responses in budding yeast.Previous studies have established the model Cat Raw in which Ddc1, a subunit of the checkpoint clamp, and Dpb11, related to TopBP1, activate Mec1 directly and control DNA damage checkpoint responses at G1